Are There Potential TRT Therapy Side Effects?


Do You Need To Worry About TRT Therapy Side Effects?

The answer is yes & no.

You need to be aware of the potential TRT therapy side effects, so it is something you can make sure is discussed with your doctor/ clinic.

I’m a big fan of TRT, without question it will deliver the best results in terms of optimising testosterone production.

However the same as with any medical procedures there are potential side effects, these can & will be mitigated by a good doctor/ clinic.

So I want the main take away from this article to be that you need to select your clinic carefully & go with a highly respected doctor.

We will take a look at the main potential TRT therapy side effects, again so you know what discuss with your doctors.

Why Would You Want To Optimize Testosterone Levels?

Optimised testosterone

I imagine you are aware of the benefits of optimized testosterone production if you are reading this article.

The above image demonstrates a lot of the key benefits; but there are more which we you can take a look at below.

  • Increased muscle mass
  • Lower body fat
  • Reduced risk of stroke
  • Improved sexual function
  • Increased energy
  • Increased confidence & motivation
  • Reduced risk of type 2 diabetes
  • reduced risk of cardiovascular disease
  • Reduced risk of developing some cancers
  • Reduced risk of depression
  • Reduced risk of dementia

For more in depth overviews for how testosterone levels impact male health, I suggest you check out the below articles.

Testosterone & Health

How Many People Experience Side Effects?

The number of people who experience immediate side effects are actually fairly low.

It should be noted that you are more likely to suffer from side effects the older you are.

Again working with a reputed clinic & doctor that you trust is imperative as well.

The Potential TRT Therapy Side Effects

doctor showing patient a computer screen

Lets take a look at some of the main potential TRT therapy side effects are. The most common ones are as follows:

  • Growth of “breast” tissue/ development of man boobs
  • Lowered Sperm Count/ Infertility
  • Oily skin & acne
  • Increased risk of blood clots
  • Testicle Shrinkage
  • Increased risk of stroke & heart attack

As you can see there are a few different side effects, most of them aren’t that pleasant.

As I’ve already advised these are all avoidable & can be mitigated.

Using a combination of the right treatment & making sure you lead the right lifestyle will ensure the side effects are successfully avoided.

So now we are going to look at each of the potential side effects in a bit more details.

Growth of breast Tissue

man with high chest fat

This is usually referred to as moobs/ man boobs or by the medical team gynecomastia.

This growth of breast tissue is usually down to an excess of estrogen.

This can occur when someone is on TRT but they haven’t suitably lowered their body fat and inflammation levels.

The high levels of body fat & inflammation, which is caused by poor diet, stress etc. actually leads to the conversion of testosterone to estrogen.

This is a process called aromatization, the way to deal with this is lose excess body fat & lower inflammation.

Lowered Sperm Count/ Infertility & Testicle Shrinkage


If you boost testosterone exogenously (not naturally), it can potentially stunt the production of the hormones that are responsible for sperm production.

The stunting of these hormones production can also lead to testicular atrophy/ testicle shrinkage.

If you are planning to start have children, this is something that needs to be considered before starting a TRT course & needs to be discussed with your doctor.

Again a good clinic will look at all the different types of treatment available to you & adapt the treatment accordingly.

Oily Skin & Acne

When serum levels of testosterone are extremely increased, an increase in the secretion of sebum can also occur.

This can lead to the development of acne. This is extremely rare & is something your doctor should be able to work with you to negate.

Increased risk of blood clots

blood cells

Studies have shown that there is fairly high risk (up to 63%) of suffering from blood clots in the first six months of TRT therapy.

The risk does decline after the initial six month period but is definitely something your doctor should be addressing with you.

Again it is very much dependent on the treatment your doctor is prescribing, a competent doctor will be able to manage this, while tracking your risk.

You can find out more about the study & get more in-depth figures & findings on the below link.

TRT Therapy Side Effects

Increased Risk Of Stroke & Heart Attack

TRT can lead to developing something called polycythemia, this occurs in over 20% of men.

Polycythemia can lead to an increased incidence of vascular events, including stroke & heart attacks.

Much the same as with blood clots, a competent doctor/ clinic will be able to prescribe correct treatment while minimizing your risk.

Already Started Or Decided To Start TRT Therapy?

If this is a path you want to go down, I hope the potential TRT therapy side effects have not put you off!

If you have primary hypogonadism (where the testicles no longer work properly) you need to go down the TRT route without question. 

The main take away from this article should be that that you need to work with a reputable clinic! 

If you have queries as to what your best option is in terms of clinics, you can drop me an email on

If you haven’t done so, I would also recommend a blood test before moving forward.

Many clinics will offer tests (and should) but if you want a test independent/ prior to engaging a clinic.

You can check out the organisations that I recommend below.

Recommended TRT Blood Test Services

Final Thoughts

I hope you have found this article on TRT therapy side effects useful.

I hope the main take aways have been clear, they are you need to engage with a reputable clinic & doctor. 

If you want a recommendation, query about what you should be discussing with them etc. just drop me an email on

You will get the most from your therapy by naturally optimising testosterone and lowering inflammation levels.

‘I’ll be publishing an article specifically looking at this shortly; but you can check out my different articles in ways to lower inflammation & naturally help increase T.

If you aren’t necessarily ready to move forward to with TRT; but are just worried you have low T levels. 

I would suggest your first step is to establish if you have low testosterone levels with a blood test. 

You can check out the blood testing services I recommend below.

Recommended Home Testosterone Tests Service

Same as always if you can share this article with anyone you think may find it useful.

You can also follow me on my social mediate sites, where I cover areas like TRT therapy side effects & how to optimize testosterone production.

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110 thoughts on “Are There Potential TRT Therapy Side Effects?”

  1. Ron says:

    Health in general is such a bit issue and reading information about such topics is important, especially when done so effectively.
    Obviously well researched.
    Thank you

    1. Nate Stone says:

      Hi Ron,

      Thanks, I’m glad you found this useful!

      Don’t get me wrong, suffering from low testosterone is worse than the potential TRT therapy side effects; but the potential negatives do need to be considered.

      You can get a better idea of the side effects of low T here, testosterone and health

  2. Ellie says:

    I like the research you mention and link to in this post, Nate. Backing up health claims with independent studies is the gold standard for a good blog post, IMHO.

    Will you be doing a follow-up post on natural ways to increase testosterone levels?

    1. Nate Stone says:

      Hi Ellie,

      Thanks I’m glad you’ve found this article useful!

      Yes I will be creating an article on ways to increase testosterone production, I suggest you check out foods that boost testosterone production and ways to increase testosterone naturally as a starting point for guidance.

  3. Shoot, I never thought about TRT before having children. That could cause some serious problems. I will definitely have to refer my friends here for them to check this out.

    I have been dealing with acne for a while actually, so it’s good to know that it’s not a problem associated with TRT usually.

    1. Nate Stone says:

      Hi Jacob,

      Yes unfortunately TRT can make potentially make infertile, yes please do advise any friends thinking about TRT therapy to take a look at this.

      It’s worth checking out foods that boost testosterone production & ways to increase testosterone naturally to get an idea of other ways to increase your T levels.

  4. Fiona says:

    Testosterone Replacement Therapy does sound like quite a drastic measure when considering the side effects that you have mentioned. Do you know how the treatment works? Is is just a matter of going in to get a shot from the doctor or do you need to take pills over a period of time?

    1. Nate Stone says:

      Hi Fiona, 

      I do think it is an extreme as your initial solution, in some cases it is required but I would always recommend trying to increase testosterone levels naturally first. You can take the treatment in a number of ways, this incudes shots, pills and gels. The different types of treatments do have slightly different risks attached and some more than health risks than others. I would recommend checking out this foods that boost testosterone production article first, as your diet is a good place to start to increase testosterone levels.



  5. Dianne says:

    Hi there,

    You say that most men and a high number of woman suffer from low testosterone. How does a person know this to be the case? What are the signs to look out for that you are suffering in this way. 

    I definitely agree with you that lifestyle changes should be tackled first and foremost. Great advise there 😉

    1. Nate Stone says:

      Hi Dianne, 

      Good question, if you check out this article on testosterone and health you’ll get an idea of the symptoms of low testosterone in men and women. 

      The best ways to test your levels are with a blood test, to get an idea of what your testosterone levels should be, check out this testosterone and health – benefits of healthy T article

  6. Jessica Lauren Vine says:

    Wow. That’s some serious side effects! I agree with you that it should only be a last effort instead of going to this right away. I am glad that you covered this in your article. I am sure there are a lot of people that have considered going with this treatment.

    1. Nate Stone says:

      Hi Jessica, 

      I’m glad you found this article useful, yes the number of men going for TRT therapy has greatly increased.I’m not saying it’s the wrong thing to do but there are times where a less extreme and cheaper approach like lifestyle changes can fix the issue, which is the case if you have slightly low testosterone levels.

  7. Chris says:

    thank you for this great post on TRT Therapy side effects.

    It is so great to know about health concerns before trying something new, some of these sound a bit scary, but it seems that it is rare. It is great that you have taken the time to share your knowledge with us all. 

    1. Nate Stone says:

      Hi Chris, 

      I’m glad you found this article useful. 

      Yes suffering from TRT therapy side effects is moderately unlikely, in a lot of cases TRT therapy isn’t required, so I’ve always been of the opinion that it’s worth trying methods other than surgery, like lifestyle change first.

  8. jeysatified says:

    Your words were spoken with we readers in mind and that’s one thing I like about this article. Furthermore I want to state that you are very correct; TRT treatment is very vital even for some women who are low on it. 

    Reading your article made me realise just how important it is.

    As per the money, don’t they say health is wealth?

    Great post and cheers!

    Sharon Jey

    1. Nate Stone says:


      I’m glad you found this article useful, yes your testosterone levels does effect a lot of areas of your health, this testosterone and health article will help you understand further why having healthy testosterone levels is so important.

      While I agree health is wealth, it is possible to achieve healthy testosterone levels without forking for therapy, this Alternatives To Testosterone Replacement Therapy article will help you work out other cheaper methods to achive increased T


  9. Marcus Crowe says:

    This is a very important topic and I think it that it was very good of you to write an article about it. Raising awareness of this is vital.

    1. Nate Stone says:

      Hi Marcus,

      I’m glad you found this useful, yes unfortunately TRT can come with side effects, if you want to increase testosterone levels but want non surgery options, I suggest you check out this Alternatives to testosterone replacement therapy article.

  10. This is a great post, more people need to be aware of the side affects for things like this.

    1. Nate Stone says:


      Thanks I’m glad you found it interesting, if you have any men in your family or your close to considering testosterone replacement therapy, please do get them to check out this site as TRT therapy side effects are really quite serious.

  11. C says:

    Thanks for the testosterone test. It sounds a lot easier than making a doctor’s appointment and having to go to that. Does trt make you dependent on exogenous testosterone for the rest of your life? That’s one of the issues with steroids is that people end up having less endogenous testosterone production since their body got used to the external hormones. 

    Also, do you know if trt is covered by Insurance in the United States? It sounds like it costs a lot and might not really be covered by insurance, so your tips on Lifestyle Changes might be better.

    1. Nate Stone says:

      Hi C, 

      Yeah the same issue can apply with TRT therapy, your body becomes flooded with testosterone so it may stop producing its own. I’m not sure about insurance cover, I’d imagine the absolute top end of insurance may cover some form of testosterone treatments. You’re correct though even if it is covered by insurance lifestyle change is best, as you don’t have the TRT therapy side effects to deal with and you don’t run the risk of your bodies natural testosterone production coming to a halt!

  12. jessetoikkanen says:

    The nice-looking site and informative article I would say! Testosterone replacement therapy is the only effective way to get your testosterone levels on the recommended level. Still, there are thousands of companies manufacturing all sorts of natural testosterone “boosters”. Practically every single clinical study clearly shows no natural micro-nutrients of super-foods have any significant effect (or actually att all) on testosterone levels. I have been working in kihu, Finnish Research Institute for Olympic Sports and among 500 tested people, half competitive sportsmen and a half “normal people” there was up to 0,1% raises on s-testosterone and no any changes on free testosterone levels in their blood. But those natural “boosters” says always it “may” raise your testo levels. I could found a company to manufacture chocolate and say it may lower your cholesterol and help with nerve pains. However, thanks for an article of only working methods to boost testosterone levels! 
    -Kind regards Jesse

    1. Nate Stone says:

      Hey Jesse, 

      I agree it is extremely hard to increase testosterone to the same amount that TRT Therapy does. It is possible to at least get to normal/ optimised levels 1000+ with lifestyle changes; but it’s not easy, it means your diet, training, and what items you use on a daily basis need an overhaul. even then it isn’t as effective as testosterone replacement therapy; but you do avoid the potential side effects. Completely agree about the majority of testosterone supplements though!

  13. DorcasW says:

    Hello; do you believe if people with Testosterone issues know that their lifestyle change can positively affect their Testosterone levels they would want to do therapy?

     I do believe that education is key to their decision on this wise. Therefore, I hope that more people will find your post and read it through with understanding so they can take the correct action.


    1. Nate Stone says:

      Hi Dorcas,

      I believe that you can do a lot to boost testosterone production through lifestyle changes. In some cases this will be enough that you don’t need to consider testosterone replacement Therapy/ TRT Therapy.

      In some scenarios TRT therapy will still be the best option; but following these tips will help improve the effectiveness of the therapy.

      I will always advise that people try these alternatives to testosterone replacement therapy as the first port of call.

  14. Scott Hinkle says:

    Thank you for this very informative post.

    I’ve seen ads and whatnot about testosterone booting but I never really thought much about side effects.

    I have to say, unless there’s a medical need for the treatment, I’d opt for lifestyle changes before even entertaining anything with such side effects.  I mean really.  I already have semi moobies, I don’t need anything adding to them!  Sadly I’m joking (but not really).

    I’m going to do a bit more digging into this and see if even a lifestyle change could produce such side effects and try to determine which changes will provide the best results without the unwanted nasties.

    Thanks again,


    1. Nate Stone says:

      Hi Scott, 

      I’m glad you found the article interesting!

      Yeah, I suggest people look at the lifestyle changes first, due to the potential TRT therapy side effects. 

      It is pretty much vital for male health that you have a healthy levels of testosterone. If you are beginning to get man boobs, it would probably suggest that your testosterone levels are least slightly on the wrong side of “normal”

      Yeah check out my ways to increase testosterone naturally, increasing T naturally doesn’t bring side effects.

      Again making sure you have at least average levels is important and if you have optimised levels your health only benefits further. 

      I suggest you check out these articles on Testosterone And Health – How Low T Negatively Impacts Health to get a better understanding of why you need healthy T levels.

  15. Wayne says:

    Hello, Nate.  This is an interesting subject but one that I haven’t really been too concerned with and perhaps I don’t need to be being that I am a septuagenarian.  However, I can see why some would want to try this therapy. I mean, it has the potential to help in so many different areas of a man’s life.  Who wouldn’t want to have those benefits?

    Testosterone levels do become less as we get older so a little bit of help would be good for some providing they are careful and stop the treatment if and when the first signs of symptoms start to show up.

    As much as I would like to have some of those benefits, I’m 70 now and really, if what you say is true, those side effects aren’t worth the risk.  I’ve already had heart by-pass surgery and wouldn’t want to run the risk of having that again.  The other side effects?  Man boobs… don’t need help there.  Sex life… could be better but I can’t complain.  Energy level… doing ok in that department.  Eat well and walk a lot.

    Anyway, as I said, I’m 70 and some of the benefits just aren’t as important to me as they would have been when I was younger.  Maybe if I was 40 or 50 and having issues that could be fixed by this treatment but not now.  I’ll leave it for those that are younger. 


    1. Nate Stone says:

      Hi Wayne,

      Thanks for your comment, I actually had no idea what a septuagenarian, I had to google that one, so thanks for dropping some knowledge on me lol.

      I’d agree that most the benefits you get from TRT in your 70’s would be a moot point. I would however suggest that, increasing your testosterone levels naturally will bring health benefits such as stronger bones, reduced risk of dementia and better heart health.

       So I’d consider checking out some of these articles on natural ways to increase testosterone, as you get the health benefits of higher T, without the potential TRT therapy side effects. 

  16. Rodarrick says:

    Well, just like you, i will consider this TRT therapy to be a last resort only after I have tried all other approaches to testosterone boosting. The pricing of the therapy is the major scare for me here. Being an average earner, adding that much to my expenditure would only bankrupt me and also, the side effects are just too massive and I am not willing to risk that much yet. Thanks

    1. Nate Stone says:

      Hey Rodarrick, 

      Yeah if you are looking achieve a testosterone booster, I would advise trying to optimise your levels naturally first. While it can very effective, the TRT therapy side effects & cost do need to be something seriously consider. In many cases lifestyle changes are enough to make a difference and TRT can be bringing a sledgehammer for a nail type scenario!

  17. Stephanie says:

    I was surprised to see that this treatment can cause infertility. Wow! I wasn’t aware that it was that expensive. I mean, living in a capitalist society can be to blame, but still, it’s a shocker. How does someone can certainly know if they’re running low on testosterone? Besides a healthy lifestyle, what else can people use to prevent deficiency?

    1. Nate Stone says:

      Hey Stephanie, 

      Yeah the treatments if not managed correctly can in reality be very dangerous & the potential TRT therapy side effects are quite worrying. The well respected clinics will advise customers of these side effects; but people need to be made aware, in case they find themselves unknowingly dealing with someone who are less than honest about the side effects. 

      I would always suggest getting your testosterone levels checked before taking any serious action, I work with a company that offer a home testosterone test 

      So having a healthier diet, increasing your resistance training and reducing your stress levels will help boost testosterone production & your health as a whole!

      On top of that it becomes about avoiding chemicals that lower testosterone & disrupt hormone balance as a whole, these chemicals are found in things most of us may use daily, you can find out more about where these chemicals are found here 24 Places Where Chemicals That Lower Testosterone Can Be Found

  18. Henderson says:

    Hello Nate, this is a very good post on this discourse. I have not given this therapy a thought yet but seeing that it has so many side effects even as much as having to go through stroke, one will have to be very careful not to fall for this one. It is very interesting to read this post here about testosterone level boosting and the TRT. I guess it will be better not to even think about the therapy. Thank you for this.

    1. Nate Stone says:

      Hi Henderson, 

      Thanks I’m glad you’ve found this article useful!

      In some scenarios testosterone replacement therapy will be required as the side effects of suffering from hypogonadism/ low testosterone are even worse! 

      That being said, I do advise that people look to increase testosterone naturally first and only consider TRT as a last resort, as the TRT therapy side effects, as you’ve rightfully pointed out can be pretty serious!

  19. John says:

    I have actually heard about this therapy before but i have not thought yet that i should give it a try. Reading this, i can see how it is not a great way to boost testosterone levels. I see all the side effects of the therapy and i feel like it is even going to cause more than what low testosterone levels would have done. It will be better to find better alternatives. Do you have a suggestion for that?

    1. Nate Stone says:

      Hi John, 

      Yeah testosterone replacement therapy is a difficult one! 

      Suffering from low testosterone/ hypogonadism is worse than TRT therapy side effects.

      Yeah I usually recommend these alternatives to testosterone replacement therapy that is assuming someone’s T levels aren’t so low that it needs immediate therapy. 

      If it is less extreme, I’m personally a believer, that trying increase testosterone levels naturally, is the healthier & far more cost effective option!

  20. Pablo says:

    Very good article. I am 43 years old and I was beginning to wonder about these therapies. I was worried about the side effects, but I didn’t really know what they were.

    This article gives me some certainty about the treatments.

    And you are quite right in what you write about starting first with more natural changes. In my case, I started exercising 1 year ago with weight and that really made me feel much more “powerful.” It improved my posture and my mood.

    I am also interested in knowing this check. I really didn’t know where they were going, but I’m going to try this test that you recommend.

    Regarding natural alternatives, which food would you recommend to complement the other solutions? I mean there is a particular diet focused on increasing testosterone levels?

    Thank you very much for the article and the information!


    1. Nate Stone says:

      Hey Jason,

      Yeah the TRT therapy side effects can be pretty serious!

      Yeah if you think you may suffer from low T, I would always advise getting your levels checked. You can see the service I recommend, in this home testosterone test article here

      There are a couple of different diets that will help increase T. You can find out more about Paleo Hack Recipes & Keto Resources

      You can also check out my 48 Foods That Boost Testosterone Production article.

  21. Wendy says:

    I found that I lost my overal energy and libido several years ago while going through the change. It was suggested that my testosterone was low. After focusing on my health and losing weight I got it all back. I have more energy and I sleep better. I really think a healthy lifestyle plays a big role in raising testosterone.

    1. Nate Stone says:

      Hey Wendy, 

      It certainly does, I’d never suggest that a woman needs testosterone replacement therapy. Suffering from low T however is bad for your health, regardless if you are male or female. 

      Yep healthy lifestyle is one of the major keys to healthy testosterone production, if you do find yourself in position where this symptoms creep up, put in to practice, some of these alternatives to testosterone replacement therapy listed here and it should naturally raise your T enough to solve the issue!

  22. cpascal says:

    Although trt can be beneficial in a lot of cases, another drawback to it is that testosterone is only available by prescription in most places. It can be hard to find a doctor who’s willing to prescribe it. The only other option seems to be the online steroid shops, which one has to worry about the legality of buying from, not to mention the safety or authenticity of the products.

    1. Nate Stone says:

      Hey Cpascal, 

      Yeah getting a prescription for testosterone certainly can be difficult and involve jumping through a lot of hoops!

      Yeah I’d avoid anabolic steroids as well, no guarantee what it is and you don’t have a doctor on hand to advise/ check certain elements of your health, to ensure the TRT therapy side effects that I listed on this article don’t happen. 

      You can get services like the Medicheck Blood Tests For TRT & Anabolic Steroid Courses which will help test your blood to make you aware if there are potential issues; but not the same as it being monitored by a doctor.

      I’d personally recommend you check out these Alternatives To Testosterone Replacement Therapy to make a start!

  23. Chris says:

    I have a teenage son who practices body building, so I know testosterone levels are important. One of his friends however has a high body fat percentage and seems to get tired more easily so we’re wondering if this will have anything to do with his testosterone levels. I agree with you that surgery is bad because of the mentioned side effects like infertility and heart diseases. Is there any other way to boost testosterone levels other than surgery? I love your specific detail about hormones. Also, I will be sure to check out the other articles about body building related issues. Thank you for this blog post, I will share this with my child and other friends.

    1. Nate Stone says:

      Hey Chris, 

      Yeah testosterone levels are very important, certainly for muscle mass gains; but for male health in particular as a whole!

      Yeah the TRT therapy side effects, really are quite scary! I’d only advise going down that route in extreme scenarios!

      Yeah I’d suggest you start off checking out this Alternatives To Testosterone Replacement Therapy

  24. Temidayo says:


    I really like the way you talked about changing ones daily routine, getting enough sleep and exercise will help boost Testosterone level. In this generation where everyone is virtually in a rat race trying to achieve one thing and another at the detriment of ones health. Its crazy. Of what use is what we are trying to achieve if our help is deteriorating in the process. 

    For me, even if the TRT Therapy cost 1cent, I will prefer to adjust my lifestyle by doing the following;

    Get more Sleep

    Play More

    Eat right

    Delegate and 

    Exercise more.

    Thanks for also providing a link to learn more about Home Testosterone test. I will go check that out. Thanks for sharing.

    1. Nate Stone says:

      Hey Temidayo,

      Yeah TRT is a difficult one, in some scenarios if your testosterone levels are very low, replacement therapy may be your only option. In any other scenario I would strongly suggest that people try these alternatives to testosterone replacement therapy first.

      You’re spot on in terms of the lifestyle changes that need to be made!


  25. vza Original says:

    I’m sure this TRT Therapy can be very helpful for some Men but it’s always good to get genuine information on such topic before considering a Therapy or treatment of any sorts. Testosteronetips net is definitely a source of information I would recommend to anyone interested in boosting their testosterone levels. 

    1. Nate Stone says:


      Thanks for your kind words!

      Yeah testosterone replacement therapy is and can be very effective, there are TRT therapy side effects though and I think it’s important that people are aware what they are!

  26. water life says:

    Another enlightening and informative article from you on testosterone. Of course I would prefer the natural ways of growing it. I didn’t know how many problems her lack of growing up could cause. Diet I believe is the key that we all need to take care of to avoid unwanted situations. Thanks for the update. I’ll share your article.

    1. Nate Stone says:


      Yeah diet is certainly a major part of this, as is how active you are, stress levels, chemicals that you’re exposed to. TRT is likely necessary if you have extremely low T levels/ hypogonadism. 

      There are a lot of scenarios however where people leap straight to TRT, where lifestyle change would be very effective. That is why I like to highlight what the TRT therapy side effects are, so people can make an informed decision.

  27. Rob S. says:

    Low testosterone is not something I thought much about.
    But I just found out that I have low testosterone so I need to do something about it.
    This TRT therapy sounds like nothing I would ever do.
    I know that everything has potential side effects but this?
    I would much rather exercise and eat better and take vitamins because there’s no side effect from that!
    Why would anyone chance doing this therapy?

    1. Nate Stone says:

      Hey Rob, 

      Sorry to hear about your diagnosis! 

      I imagine if you are on low on T, this is going to be something that your doctor strongly recommends, there are TRT therapy side effects; but the side symptoms of low testosterone/ hypogonadism are even worse!

      If your case is an extreme one and your doc is advising you need to go on TRT immediately, I’d heed their advice. If it is a scenario where they’ve advised your T levels need increasing/ optimising but it it’s not dire, then I would advise lifestyle changes etc. which I talk about at length on this site.

      In some cases not getting TRT can be potentially fatal, so in those scenarios, it is 100% the right thing to do, you just need to make sure, you’re working with someone reputable!

  28. Mr Biizy says:

    Hi Nate. Thank you so much for sharing such an educative, informative and life saving article about the potential testosterone therapy. Increasing the testosterone level in our bodies is so so beneficial I see from the post. And oh, I’m young in my middle twenties; I shouldn’t be scared of side effects, right?? 🤔

    1. Nate Stone says:


      Yeah increasing or optimising your testosterone levels is very important for your health and especially as male.

      If you are in your mid 20’s, unless you are suffering from extremely low testosterone/ hypogonadism I would recommend lifestyle change as supposed to TRT.

      If you did decide replacement therapy is the way you wanted to go, you would still be suceptible to the TRT therapy side effects, that is why i would suggest you look at lifestyle change, especially as a young man.

      I’d also advise getting your hormone levels tested, so you can understand wher your hormone levels sit, if you are low on testosterone or if other hormones are out of sync. This will help you udnerstand your health better & decide courses of action to address!

  29. Benson says:

    There are always a better means of getting to deal with health issues rather than surgery and drugs all the time. I am not really a fan of these things because of the possible side effects that goes with it after its all done. Treating testosterone level by surgery is a really weird thing to me and you have also started the side effects which isn’t a minor thing at all. I will always suggest the more natural means than surgery.

    1. Nate Stone says:

      Hey Benson, 

      Yeah the TRT therapy side effects, certainly aren’t a joke!

      Yeah in some scenarios testosterone replacement therapy is needed; but in a lot of scenarios you can increase your T levels naturally, through diet & lifestyle and that is the better option, it’s certainly cheaper and you avoid the potential side effects!

  30. Travis says:

    As I have gotten older I have worried about lower testosterone levels, and even considered testosterone replacement therapy. I will not be having any more kids so that is one less thing to worry about fortunately, but some of these other side effects are worrisome. Thank you for the links to look into this, to see if TRT would be something that would help me and to get it started if need be!

    1. Nate Stone says:

      Hey Travis, 

      If you are suffering from low testosterone, I would strongly advise working on increasing your levels, as low testosterone is very serious and negatively impacts sexual, mental, emotional & physical health, low T can even potentially be fatal and lowers your life expectancy. 

      TRT is a difficult one, while there the TRT therapy side effects, these side effects are in fact now where near as bad as what you can suffer as a result of low T/ hypogonadism.

      In some scenarios, TRT is going to be your only option; but I’d usually advise that people try to increase their testosterone levels naturally with lifestyle changes.

  31. Nuttanee says:

    I have been considering Testosterone Replacement Therapy for my husband. He has recently been unable to focus and his mood swing is the worst and I did my research and found that increase his testosterone can help. However, I want to make sure that it is safe, thanks to your post. I also read that because of our exposed to chemicals in the daily products, I am exposed for too much Estrogen as well and that can harm my health. 

    Now that I read your post I am concerned. I think it is best to change our lifestyle first, the side effects are horrendous. Will try out the kit and take it from there. Thanks for the discount code and you amazing review 🙂

    1. Nate Stone says:

      Hi Nuttannee,

      Yeah I would always advise lifestyle changes first, if his testosterone levels are so low that they aren’t able to be increased fast enough, I’d then recommend considering TRT.

      While the side effects of TRT are pretty bad, what happens when you suffer from low testosterone is even worse!

  32. KingAndrea says:

    This is very helpful, I’ve being reading about TRT for a while now but this is the first time any article will include it’s side effect that I’m aware of. I think it’s very important for people to understand the fact about these things they do to their health. If I may ask, is there any way TRT can be done without being affected by these side effects? 

    1. Nate Stone says:

      Hey Andrea, 

      Yeah the TRT therapy side effects can be pretty serious!

      The symptoms of low testosterone are even worse though, TRT can be perfectly safe, you just need to make sure you work with a highly reputable clinic, who keep track of your key health markers, to make sure if you are at risk of these side effects, that they are mitigated.

  33. Rachel Herrera says:

    This is a very interesting article. My father in law is doing hormone therapy and has had a huge increase in energy, resulting in weightloss and increased stamina in his runs. There is something to be said about hormone balance and the significance it has on our health. Are there any products or supplements that you recommend to help people stabalize or detox from excessive hormones that keep the testosterone from doing its job?

    1. Nate Stone says:

      Hi Rachel, 

      Good news about your father in law! 

      Yeah in terms of hormone balance a supplement I’d recommend is something called DIM it flushes out excess estrogen and helps balance out hormone levels. 

      I’m not sure where you’re based but a UK brand I recommend is Estrohalt if you’re US based I’d recommend Smoky Mountain

      If you are based elsewhere, let me know and I can recommend a different brand.

  34. Stratos K says:

    When it comes to medication and treatments I was always of the opinion that if it’s not something health threatening it should first be treated by a change of diet and way of life and only if that doesn’t work to end up to treatments like this. Although I am not very familiar with TRT everything that has to do with our health should be treated with extreme caution as there are many so called experts that can only do things worse. Thanks for the info you provide and hopefully people will learn to be more careful with the most precious thing we have in this world. Our health.

    1. Nate Stone says:

      Hi Stratos,

      You’re correct, suffering from low testosterone leads to a number of health issues and can potentially be fatal! While the potential TRT therapy side effects aren’t quite as bad as this, they aren’t pleasant either.

      While there are some scenarios where TRT is absolutely necessary, in most scenarios people don’t need to take this route and can make diet & lifestyle changes to fix their testosterone levels. Precisely I’m just hoping people are more cautious before taking a step that is undoable, I’m not anti TRT, just think everyone should know the full picture!

  35. Andrew says:

    Hi Nate,

    thanks for another great article – this time on testosterone replacement therapy. As a 52 year old man, I think its important to make sure we have enough testosterone. I am fit and healthy and regularly lift heavy weights in the gym which helps with testosterone production, but I still worry that my T could be low with the pressures of modern societies diet and chemical influences. I have just been on the medichecks website through your link and they have a 25% off sale ending at midnight so I’ve ordered a kit. I will let you know my result. Thanks again, Andrew

    1. Nate Stone says:

      Hi Andrew,

      Yeah healthy T levels become even more important as we age as this is when they start to dip even more.

      Lifting weights and a healthy diet will help with your T production; but you’re right with the number of chemicals we’re exposed to and our lifestyle, you’re still at risk of potentally having low T. Excellent, getting your T levels tested is the way to go, yeah let me know what your results are and we can discuss what may be the best action for you to take movinmg forward.

      TRT may be the best option for but barig in mind potential TRT therapy side effects, I prefer to avoid that route for people, when it isn’t a necessity.

  36. Stacy says:

    I found your article informative!  For me the risks seem to outweigh the benefits.  There is a delicate balance of hormones in the body that I don’t think modern medicine fully understands.  I was just speaking with a client yesterday about Estrogen replacement therapy in menopausal women.  Her comment was that two of her friends chose to use an estrogen patch through menopause and now have breast cancer. Your education on potential side effects was very helpful!

    1. Nate Stone says:

      Hi Stacy,

      Yeah it is a difficult one, I think it depends on how low testosterone levels are and what the cause is. In many cases T levels can be raised enough with lifestyle change.

      The potential TRT therapy side effects are pretty scary, I don’t think they are worse than suffering from legitimate low testosterone levels; but a lot of people take TRT unvessarily, which opens them up to unnecessary risk.

      Yep people need to be very careful with hormone levels & understand the risks of artificially increasing hormone levels.

  37. Katja says:

    Having no previous knowledge about TRT therapy, your post gave me a lot of valuable information.

    I did not know that low testosterone levels can affect dementia and depression. But I guess at the end of the day, everything is connected  within our body. That is why it is so important to lead a healthy lifestyle.

    I love how you suggested to first do some work on ourselves, by changing lifestyle – making sure diet is on point, excercising.. – and then consider TRT therapy, if nothing else heps us…

    1. Nate Stone says:

      Hi Katja

      Yeah the TRT therapy side effects can be petty scary; but in reality suffering from low T is in fact worse than any potential TRT therapy side effect.

      While a lot of people likely have low testosterone levels; the majority won’t need to resort to replacement therapy, that is why I suggest trying to increase T levels naturally initially.

  38. Teresa says:

    Hi Nate

    I found your article really interesting and quite an eye opener! There are really some nasty side effects related to TRT and I just wondered, how would someone know if they were low in testosterone? Are there common symptoms to look out for?

    I guess your message rings true when your diet and lifestyle should really be considered and changed first before undergoing any sort of radical treatment/therapy that has any side effects attached to it.

    Thanks for the info.


    1. Nate Stone says:

      Hi Teresa, 

      Thanks, I’m glad that you found it interesting.

      There are some really potentially nasty TRT therapy side effects, that being said, they are still better than the symptoms of suffering from low testosterone. 

      Yeah there are some common symptoms of low T which you can check out in this Testosterone And Health article

      Yep it’s usually lifestyle that has caused the issue in the first place, so makes sense that changes in lifestyle help to fix it. 

  39. PeterMinea says:

    Hello Nate!

    Quite an interesting article about our main hormone! We men may experience serious problems with its production, and thus with our life itself. Producing better T levels makes us manlier!

    TRT therapies may not be available to everyone, so it’s very true that the first solution we have for tackling the problem of low testosterone levels is changing our lifestyle (by a better alimentation, enough sleep…). The side effects of trying to solve that problem medically may be pretty serious: if I wanted to increase my T level and if I also had to choose between TRT and a natural solution, I would rather go for the natural way of things.

    Developing those so-called “man boobs” is not desirable, and testicle shrinkage neither, not to mention other risks (well, many of us experienced acne while in the puberty years, but as adults that’s not welcome).

    Thanks for exposing these risks of TRT in your article! Other men who may be interested in increasing their T lavals artificially should benefit from your information, without making quick choices.

    Best regards,


    1. Nate Stone says:

      Hi Peter,

      Yep testosterone certainly is the main male hormone. Yeah our T levels are essentially tied to our “manliness” but also our health as a whole!

      Yeah TRT isn’t available to everyone and perhaps most importantly isn’t a necessity for everyone who has low T. A lot can be done to improve levels with lifestyle change, with things like getting enough sleep, changing your diet, exercise etc.

      Yeah I’d always advise that people look at natural ways to increase T first, as the potential TRT therapy side effects aren’t pleasant. That being said there will be scenarios where people need to opt for TRT, in that scenario it’s still preferred to suffering from low testosterone.

      Yeah I’m just trying to give men the info they need, to make an informed decision and not rush ahead in to something they may regret.

  40. Son says:

    Hello, I really appreciate your time and effort on writing about testosterone replacement therapy which is something that I’ve considered since I’ve always felt that I needed, however the side effects such as man boobs, oily skin and acne, and shrinkage of testicles kind of scares me.

    The way you laid it out is perfect and informative, I’m definitely gonna consider this as a last resort, I may try implementing a more healthy diet and exercise routine first to see how it works for me. Thanks for bringing it to my attention!

    1. Nate Stone says:


      Glad you found the article useful, there are certain scenarios where TRT is necessity but there are plenty of scenarios where you don’t have to go down that route. 

      This is why I like to make people aware of what the main TRT therapy side effects are, so they definitively put thought in to deciding and researching if it’s right for them. 

      Yeah I’d try lifestyle change first, if that isn’t working then consider looking at TRT, although the TRT therapy side effects aren’t desirable, suffering from low testosterone is even worse!

  41. Joy gateru says:

    Wonderful!! I was thinking of undergoing TRT therapy soon, but I decided to check out on the side effects, ooh! What a great revelation, most of the adverts states that there are no side effects, but here you explain them all, I believe that it feels nice to have big muscles, and mostly increased sexual power, but having read the risks involved in it later on, I just have some doubts on the TRT,  personally I hate acne, more also I can imagine having a low count of sperms and risking blood pressure, hell no….I better stay natural. Thank you for sharing such an informative post, I believe it will be of great help to many people out there.

    1. Nate Stone says:

      Hey bud, 

      Yeah TRT serves an important purpose. It’s a necessity if men suffer from low testosterone and T levels can’t be increased in other ways. 

      If managed correctly, you should suffer from the TRT therapy side effects; but it’s very expensive and seeing as most people can actually optimise/ increase testosterone levels naturally, that is the route I would suggest trying, at least at first.

  42. daren says:

    hello thanks for this important review. In 2015, as part of its advisory on cardiovascular risk, the FDA issued a
    safety announcement saying that TRT is approved only for use in some men which are men with low
    testosterone concentrations caused by hypogonadism and it was made clear that it should not be
    used in those with age-related low testosterone. the side effects you have listed here will help people weigh their options . thanks

    1. Nate Stone says:

      Hey Darren, 

      Completely agree, the only scenario where people need to look at TRT is when they have legitimate hypogonadism. Even then, it can still be potentially revered with lifestyle change. 

      Yep that was the idea, I’m not anti TRT, I just want to raise awareness of what the most common TRT therapy side effects are, so men can make an educated decision and decide if it’s definitively the best option for them.

  43. EVA says:

    Hi Nate, thank you for your article on testosterone therapy side effects. Before I did not know about testosterone before coming across your website, Your post contains valuable and clear information. I enjoyed every line and we can feel that you master the subject. Thank you for your recommendation! Thank you for saving life!

    1. Nate Stone says:


      I’m glad I could provide some useful info to you. 

      If you know any men who are considering TRT, please send them this way, so they can at least get an understanding of the main potential TRT therapy side effects and decide if it’s right for them.

  44. Cathy says:

    I wonder how many men out there actually use TRT for boosting masculinity and muscle mass? I mean the increase in blood clots alone is worrying because that’s a potential risk for heart attack. Are these side effects reversible when the therapy is discontinued? It sounds pretty risky to me.

    1. Nate Stone says:

      Hi Cathy, 

      Yeah a lot of men look at TRT just to increase muscle mass, which in reality isn’t what it was designed for. It’s very expensive, the potential TRT therapy side effects are pretty scary & in lot of scenarios testosterone can be increased quite effectively with lifestyle change. 

      The side effects can be reversible, the problem with TRT is that it’s for life, once you start you can’t stop as the benefits come to an end as well.

  45. Douglas says:

    So you are telling me that we should really go out and get tested for this?  I mean only if the issues have been standing out and worried about it.  Are there any other products you would recommend that wouldn’t have such a high cost to a person with low T?  Any natural herbs or supplements that could be taken on a daily basis to increase the low T without having tons of added expense?  I love all of your great information and we all should look into this if we are seeing any symptoms from low T.  Thank you for the great article and I will be checking out my body for any of the concerns.


    1. Nate Stone says:

      Hi Douglas, 

      Sadly testosterone levels are at an all time low across all age groups. This can cause a number of health problems. Such as fatigue, depression, increased risk of stroke, lack of muscle, high levels of body fat, increased risk of dementia later in life, so it’s a pretty big thing.

      So unless you are extremely fit I’d suggest it’s something that men need to look at.

      Yeah the TRT therapy side effects are pretty extreme, so understand your reluctance to go for it, diet, exercise and lifestyle change can all help increase testosterone.

      You can also get supplement like Military muscle which you can learn more about below.

      Military Muscle Testosterone Booster Review

      I do recommend lifestyle change first & you can check out my various articles on diet, lifestyle and exercise for more info. Any questions, just drop me a comment!

  46. Andrew Goodrich says:

    This was very informative for me.  I have minimal knowledge about TRT Therapy and especially the side effects.  It is great to know that sleep, diet and exercise can improve testosterone levels and should be the route to take with your primary care doctor.  I am intrigued by the home testing kits, which could be helpful for those without insurance and not having to go in to the doctor multiple times while trying to improve without TRT.  The side effects, although low, are a little scary.  Would you happen to have any information on the percentages of impacted therapy recipients. 

    1. Nate Stone says:

      Hi Andrew,

      I’m glad that you found this useful! Yeah TRT therapy has only risen in popularity over the past couple of years, so the TRT therapy side effects haven’t been spoken about that much.

      Yeah getting a decent amount of sleep every night, sorting out your diet and resistance are the three easiest things to start doing to naturally increase testosterone production.

      Yeah so the testing kits I’ve mentioned there ae for people on TRT, to help track that it is working in terms of increasing testosterone & not causing issues from a perspective of the potential side effects. You can also get more standard testosterone tests, to just understand where your testosterone levels lie. You can find out about both types of tests on the link I provided.

      The side effects aren’t that common; but just something people need to consider. No hard stats about side effects right now; but I keep an eye out for these things, so will update as & when something decent is available!

  47. Jose says:

    I know I can benefit from an increase in testosterone, but I am very concern about the testosterone replacement therapy. Your are pointing out to clear risks in this article. But even if it weren’t a risky therapy, it would not be the best option for me because I am retired with limited funds. I will seek other alternatives.

    I am looking forward to reading more of your articles on this topic.

    1. Nate Stone says:

      Hi Jose,

      Yes essentially all men can benefit from an increase in testosterone (or at least most). Yeah I can understand why you are worried about the TRT therapy side effects, with the cost potentially being one of the main “sticking points”

      yeah I’ve published a number of articles about ways to naturally optimise your testosterone levels. I’d suggest looking at the diet ones as a starting point.

  48. Jordan says:

    It is clear that TRT Therapy has many benefits associated to it, I consider most of the benefits listed in the article as essential and maybe life-changing to some men. After reading the post I find it a necessity to check my Testosterone levels, I will definitely do the home test myself, and why not go for the therapy as long as it is supervised by a doctor I think side effects can be prevented. 

    1. Nate Stone says:

      Hi Jordan,

      Yes TRT therapy does come with many benefits, the impact of suffering from low testosterone is certainly worse than TRT therapy side effects.

      Yeah I’d certainly consider getting your testosterone levels checked, if you feel like they may be low. Yes I think the side effects can be prevented if you’re closely monitored.

      What I would say is that a lot of low testosterone cases are as a result of lifestyles and making lifestyle changes can fix the issue.

      I’d suggest lifestyle change first and then look at TRT if that doesn’t work, as once you start TRT, it’s something that you need to stay on for life.

  49. The Family Explorers says:

    I have not considered testosterone levels with women. It’s something to be aware of. I was not aware of the TRT. Apparently this gets pretty deep as a topic. A “Lifestyle Upgrade” is always something to do first before anything when it comes to health. I’m glad it’s pointed in this article as well. This approach usually takes care of multiple concerns at once.

    1. Nate Stone says:


      So yes women produce testosterone as well, from the ovaries. They don’t need anywhere near the levels of men but still need healthy levels for things like muscle mass, fat loss, bone strength, heart health & mood health to name a few things. 

      Too little testosterone or too much estrogen can cause multiple health issues. I wouldn’t recommend TRT for women as T levels don’t need to be that high but naturally increasing T levels will help maintain the healthy balance between testosterone and estrogen.

      A lot of men are now considering TRT and that is where the potential TRT therapy side effects can become an issue, the majority of times improving diet and lifestyle can fix the issues & you avoid the potential side effects. 

  50. Nathaniel says:

    Hi Nate – The testosterone issue is a big one!  I have mine checked often and so far they have been normal.  I am in complete agreement that lifestyle changes are the way to go.  There are also products with natural ingredients that enable the body to produce more testosterone on its own with none to little side effects.  I believe in trying the natural way first!

    Thanks for this opportunity!

    1. Nate Stone says:

      Hey Nathaniel,

      That’s excellent! 

      Getting your testosterone levels checked puts you way ahead of most men. I agree apart from some fairly extreme circumstances, you don’t need to look at TRT. The TRT therapy side effects are a massive issue and the cost, so good to hear you’re using natural methods to optimise T.

      If you have any questions, just drop me a comment.

  51. Hamish58 says:

    Wow this was an eye opener.  I had no idea at all that TRT could result in this list below. I knew about only two of them and was hugely surprised by five of them and I have  a question about one of them:

    Lowered bodyFat , Reduced risk of stroke, Reduced risk of type 2 diabetes, Reduced risk of developing some cancers, Reduced risk of depression & degenerative issues like dementia,  all a huge surprise!

    Improved sexual function,Increased energy, knew about these two only.

    Increased confidence & motivation how do we know about this one what is the evidence?

    Fascinating post thanks

    Hamish 🧐

    1. Nate Stone says:

      Hey Hamish,

      Yeah so the benefits are very impressive and they are based on fixing the issues that can be caused by suffering from low testosterone.

      With regards to increased confidence & motivation, the evidence is anecdotal based (as it’s hard to measure feelings); but a common benefit of TRT or increasing testosterone as a whole is improvements in these areas & there are thousands of people who advise they feel their life has improved in this respect.

      While the benefits of TRT are fantastic, I have to stress that the potential TRT therapy side effects are no joke. If you are going to go down that route, you need to do your research and make sure you work with a highly reputable firm to make sure any potential side effects are well managed.

  52. The Forty Something Traveller says:

    These are some major side effects! Thanks for sharing this well researched post, I’m sure there’s a lot of people who go straight to the ‘short-cut’ and choose TRT when they could make some simple diet and lifestyle choices as you mention. You’ve provided some really great info here, I hope more people are able to read it. 

    1. Nate Stone says:


      Yeah there some of the potential TRT therapy side effects are pretty scary! es there are a lot of pople who take the short cut, jump straight in to TRT, whereas in reality they could save them selves a lot of money & potentially from these side effects with some simple lifestyle changes.

      The other issue a lot of the people who jump straight to TRT don’t necessarily do their research first, you need to work with a highly reputable clinic so the potential side effects are well mitigated, most the issues tend to come from people who have worked with less reputed or inexperienced clinics.

  53. Sphiwe Dubandlela says:

    Thank you for a well-balanced article, I am always wary of side effects, as much as the number of benefits seem to outweigh the side effects I think the severity of the later should really make one think trice before they go the therapy route.

     Personally I would rather take the longer route of consulting with my doctor before any action, I hear you that you say it has many hoops but your doctor has your medical history so they would know if you are likely to succeed or not.

    Thanks, Ron for your work, much appreciated

    1. Nate Stone says:

      Hi Sphiwe,

      Thanks for your comment.

      Being wary of potential side effects is always very sensible!

      While in a lot of scenarios I’d agree that consulting your GP is best before starting medication, TRT therapy is slightly different, sadly most GP’s have little knwoledge about hormone health as a whole.

      What I suggest to people is that they seek out a highly reputable TRT clinic, who should advise what the potential TRT therapy side effects are, then consider with those side effects in mind & what the doctors at the clinic say, decide if TRT is right for them or whether should consider looking at natural alternatives at least in the first instance.

  54. Nimrodngy says:

    Hello. Thanks for sharing  this amazing and informative article about TRT Therapy side effects.

    Being a gym addicted i always think about to increase my testosterone level. This can help me to increase my muscles and have a better confidence about my performance at the gym.  Reading this post i realized that if i try to boost testosterone level not naturally i will suffer a lot. This scared me especially the infertility and the risk of increasing the hear attack.

    I will share this useful article on my social media account. Wish you all the best! 

    1. Nate Stone says:

      Hi Nimrodngy

      Thanks for your comment, yeah the potential TRT therapy side effects are pretty scary. This tends to be more of an issue when your therapy isn’t managed correctly!

      That being said, most people don’t need TRT till later in life (looks like you’re a young man). Due to the potential side effects and the fact most people can increase T levels naturally, I do always advise people try to increase T levels naturally & then if that isn’t enough, look at TRT as a final solution!

  55. redzar says:

    I will take the advice of lifestyle change first before going through the TRT Therapy. If all things still point out the need for a therapy then by all means I’d resort to that. Exhaust first many options. It appears that the side effects have to be considered vis-à-vis the benefits of the therapy.

    The blog is extensive in its information so as to make one arrive a good decision.

    1. Nate Stone says:


      Yeah the side effects of TRT therapy are quite scary, scaring people isn’t the aim, as if you work with a reputable & knowledgeable clicnic/ doctor the side effects can largely or completely be mitigated.

      What I think the biggest problem is, that a lot of people opt for testosterone replacement therapy when in a lot of cases low T can be addressed through lifestyle change, that is what I want people to get from this.

      Not to unnecessarily expose yourself to the potential TRT therapy side effects, good to know your on my page, any questions etc. just let me know!

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